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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50277790
Substrate/Competitorn/a
Meas. Tech.ChEMBL_501320
IC50 70±n/a nM
Citation Imbriglio JEChang SLiang RRaghavan SSchmidt DSmenton ATria SSchrader TOJung JKEsser CTaggart AKCheng KCarballo-Jane EGerard Waters MTata JRColletti SL GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett 19:2121-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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  Blast E-value cutoff:
BDBM50277790
n/a
NameBDBM50277790
Synonyms:5-(3,5-difluorophenyl)-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole | CHEMBL507182
TypeSmall organic molecule
Emp. Form.C13H10F2N6
Mol. Mass.288.2555
SMILESFc1cc(F)cc(c1)C1Cc2[nH]nc(c2C1)-c1nnn[nH]1
Structure
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