| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase C |
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| Ligand | BDBM50277583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_501652 (CHEMBL993742) |
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| IC50 | 65±n/a nM |
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| Citation |  Pollard, JR; Mortimore, M Discovery and development of aurora kinase inhibitors as anticancer agents. J Med Chem52:2629-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase C |
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| Name: | Aurora kinase C |
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| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
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| Type: | Enzyme |
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| Mol. Mass.: | 35602.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
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| Residue: | 309 |
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| Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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| BDBM50277583 |
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| n/a |
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| Name | BDBM50277583 |
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| Synonyms: | 2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5 | 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine | Aminopyrimidine, 9 | CHEMBL482967 | CYC-116 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N6OS |
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| Mol. Mass. | 368.456 |
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| SMILES | Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 |
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| Structure | 
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