Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Cannabinoid receptor 1 | ||
Ligand | BDBM50258654 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_523688 (CHEMBL997203) | ||
Ki | 200±n/a nM | ||
Citation | Manera, C; Saccomanni, G; Adinolfi, B; Benetti, V; Ligresti, A; Cascio, MG; Tuccinardi, T; Lucchesi, V; Martinelli, A; Nieri, P; Masini, E; Di Marzo, V; Ferrarini, PL Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists. J Med Chem52:3644-51 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cannabinoid receptor 1 | |||
Name: | Cannabinoid receptor 1 | ||
Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 52868.96 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P21554 | ||
Residue: | 472 | ||
Sequence: |
| ||
BDBM50258654 | |||
n/a | |||
Name | BDBM50258654 | ||
Synonyms: | CHEMBL466047 | cis-N-(4-Methylcyclohexyl)-1-(p-fluorobenzyl)-1,8-naphthyridin-2(1H)-on-3-carboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C23H24FN3O2 | ||
Mol. Mass. | 393.454 | ||
SMILES | C[C@H]1CC[C@H](CC1)NC(=O)c1cc2cccnc2n(Cc2ccc(F)cc2)c1=O |r,wD:4.7,1.0,(32.36,5.84,;31.02,5.07,;29.69,5.84,;28.35,5.07,;28.35,3.54,;29.69,2.76,;31.02,3.53,;27.02,2.76,;25.69,3.53,;25.68,5.07,;24.36,2.76,;23,3.53,;21.67,2.74,;20.33,3.51,;19,2.74,;19,1.19,;20.34,.42,;21.68,1.19,;23.02,.42,;23.02,-1.12,;24.36,-1.88,;24.36,-3.41,;25.69,-4.17,;27.02,-3.4,;28.36,-4.16,;27.01,-1.87,;25.69,-1.11,;24.36,1.2,;25.7,.43,)| | ||
Structure |