Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50268294 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_523445 (CHEMBL1008297) |
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Ki | 13±n/a nM |
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Citation | Pierson, PD; Fettes, A; Freichel, C; Gatti-McArthur, S; Hertel, C; Huwyler, J; Mohr, P; Nakagawa, T; Nettekoven, M; Plancher, JM; Raab, S; Richter, H; Roche, O; Rodríguez Sarmiento, RM; Schmitt, M; Schuler, F; Takahashi, T; Taylor, S; Ullmer, C; Wiegand, R 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. J Med Chem52:3855-68 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | HH3R | HRH3_RAT | Hrh3 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48607.98 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 445 |
Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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BDBM50268294 |
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n/a |
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Name | BDBM50268294 |
Synonyms: | CHEMBL520148 | morpholino(5-(1-(oxetan-3-yl)piperidin-4-yloxy)-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)methanone |
Type | Small organic molecule |
Emp. Form. | C23H28F3N3O4 |
Mol. Mass. | 467.4813 |
SMILES | FC(F)(F)Cn1c(cc2cc(OC3CCN(CC3)C3COC3)ccc12)C(=O)N1CCOCC1 |
Structure |
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