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Reaction Details
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TargetHistamine H3 receptor
LigandBDBM50247053
Substrate/Competitorn/a
Meas. Tech.ChEMBL_523727 (CHEMBL1007534)
Ki 0.16±n/a nM
Citation Pierson, PDFettes, AFreichel, CGatti-McArthur, SHertel, CHuwyler, JMohr, PNakagawa, TNettekoven, MPlancher, JMRaab, SRichter, HRoche, ORodríguez Sarmiento, RMSchmitt, MSchuler, FTakahashi, TTaylor, SUllmer, CWiegand, R 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. J Med Chem52:3855-68 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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  Blast E-value cutoff:
BDBM50247053
n/a
NameBDBM50247053
Synonyms:1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine | CHEMBL462605 | Tiprolisant
TypeSmall organic molecule
Emp. Form.C17H26ClNO
Mol. Mass.295.847
SMILESClc1ccc(CCCOCCCN2CCCCC2)cc1
Structure
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