| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50250191 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_498766 (CHEMBL1021958) |
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| IC50 | 12690±n/a nM |
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| Citation |  Kang, DH; Jun, KY; Lee, JP; Pak, CS; Na, Y; Kwon, Y Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem52:3093-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50250191 |
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| n/a |
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| Name | BDBM50250191 |
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| Synonyms: | 3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-nitroquinolin-4(1H)-one | CHEMBL491348 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H10Cl3N3O4 |
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| Mol. Mass. | 426.638 |
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| SMILES | CC(=O)c1c(Nc2ccc(Cl)cc2Cl)nc2c(cc(Cl)cc2c1O)[N+]([O-])=O |
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| Structure | 
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