Ki Summary

Reaction Details

Report a problem with these data

Target

Cathepsin B

Ligand

BDBM50073850

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_498766 (CHEMBL1021958)

IC50

1360±n/a nM

Citation

Kang, DH; Jun, KY; Lee, JP; Pak, CS; Na, Y; Kwon, Y Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem52:3093-7 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cathepsin B

Name:

Cathepsin B

Synonyms:

Type:

Enzyme

Mol. Mass.:

37819.69

Organism:

Homo sapiens (Human)

Description:

gi_63102437

Residue:

339

Sequence:

MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI

BDBM50073850

n/a

Name

BDBM50073850

Synonyms:

(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid | CHEMBL423112 | MDL-28170 | [(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | benzyl (2S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate | benzyl (S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate

Type

Small organic molecule

Emp. Form.

C22H26N2O4

Mol. Mass.

382.4528

SMILES

CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O |r|

Structure