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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249106 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499970 (CHEMBL1019340) | ||
| Ki | 2.9±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50249106 | |||
| n/a | |||
| Name | BDBM50249106 | ||
| Synonyms: | 15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL475159 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H18N2OS | ||
| Mol. Mass. | 346.445 | ||
| SMILES | CC1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1nccs1 |TLB:0:1:4.9:11.16,8:9:2.1:11.16,12:11:4.9:2.1,THB:17:1:4.9:11.16,(-8.34,-14.91,;-7,-15.69,;-6.49,-16.46,;-6.48,-18.65,;-8.35,-19.17,;-9.7,-19.94,;-11.03,-19.17,;-11.03,-17.62,;-9.7,-16.85,;-8.39,-17.77,;-7,-17.11,;-5.46,-18,;-4.19,-17.26,;-2.91,-18,;-2.91,-19.48,;-4.19,-20.22,;-5.47,-19.48,;-6.24,-14.35,;-7.03,-13.02,;-4.7,-14.33,;-3.94,-12.98,;-2.4,-12.8,;-2.1,-11.29,;-3.44,-10.53,;-4.58,-11.58,)| | ||
| Structure | 
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