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TargetGlucocorticoid receptor
LigandBDBM50249143
Substrate/Competitorn/a
Meas. Tech.ChEMBL_499970 (CHEMBL1019340)
Ki 3.9±n/a nM
Citation Yang, BVVaccaro, WDoweyko, AMDoweyko, LMHuynh, TTortolani, DNadler, SGMcKay, LSomerville, JHolloway, DAHabte, SWeinstein, DSBarrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucocorticoid receptor
Name:Glucocorticoid receptor
Synonyms:GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:Enzyme
Mol. Mass.:85656.87
Organism:Homo sapiens (Human)
Description:P04150
Residue:777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50249143
n/a
NameBDBM50249143
Synonyms:15-ethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL472801
TypeSmall organic molecule
Emp. Form.C22H20N2OS
Mol. Mass.360.472
SMILESCCC1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1nccs1 |TLB:1:2:5.10:12.17,9:10:3.2:12.17,13:12:5.10:3.2,THB:18:2:5.10:12.17,(-9.76,-32.3,;-8.42,-31.52,;-7.08,-32.3,;-6.57,-33.07,;-6.56,-35.26,;-8.43,-35.78,;-9.77,-36.55,;-11.11,-35.78,;-11.1,-34.23,;-9.78,-33.46,;-8.47,-34.38,;-7.08,-33.71,;-5.54,-34.61,;-4.27,-33.87,;-2.99,-34.6,;-2.99,-36.09,;-4.27,-36.83,;-5.55,-36.09,;-6.32,-30.96,;-7.11,-29.63,;-4.78,-30.94,;-4.02,-29.6,;-2.49,-29.42,;-2.18,-27.91,;-3.53,-27.15,;-4.66,-28.19,)|
Structure
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