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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249197 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499970 (CHEMBL1019340) | ||
| Ki | 37.8±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50249197 | |||
| n/a | |||
| Name | BDBM50249197 | ||
| Synonyms: | (15S)-8-cyano-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL473802 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H17N3OS | ||
| Mol. Mass. | 371.455 | ||
| SMILES | C[C@@]1(CC2(C#N)c3ccccc3C1c1ccccc21)C(=O)Nc1nccs1 |r,wU:1.22,wD:1.0,TLB:19:1:6.11:13.18,10:11:2.1:13.18,14:13:6.11:2.1,THB:0:1:6.11:13.18,(33.18,-29.81,;32.42,-31.15,;32.93,-31.92,;32.94,-34.11,;32.92,-35.65,;32.9,-37.18,;31.07,-34.63,;29.72,-35.4,;28.39,-34.63,;28.39,-33.08,;29.72,-32.31,;31.03,-33.23,;32.42,-32.57,;33.96,-33.46,;35.23,-32.72,;36.51,-33.45,;36.51,-34.94,;35.23,-35.68,;33.95,-34.94,;31.08,-30.37,;31.07,-28.83,;29.74,-31.15,;28.4,-30.37,;26.99,-31.01,;25.96,-29.86,;26.73,-28.52,;28.24,-28.84,)| | ||
| Structure | 
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