Reaction Details | |||
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Target | Progesterone receptor | ||
Ligand | BDBM50249193 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_499977 (CHEMBL1022889) | ||
Ki | 147±n/a nM | ||
Citation | Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Progesterone receptor | |||
Name: | Progesterone receptor | ||
Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone | ||
Type: | Protein | ||
Mol. Mass.: | 98979.52 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P06401 | ||
Residue: | 933 | ||
Sequence: |
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BDBM50249193 | |||
n/a | |||
Name | BDBM50249193 | ||
Synonyms: | (15R)-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL514646 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H18N2OS | ||
Mol. Mass. | 346.445 | ||
SMILES | C[C@]1(CC2c3ccccc3C1c1ccccc21)C(=O)Nc1nccs1 |r,wU:1.0,wD:1.20,TLB:0:1:4.9:11.16,8:9:2.1:11.16,12:11:4.9:2.1,THB:17:1:4.9:11.16,(7.07,-47.06,;8.41,-47.83,;8.92,-48.6,;8.93,-50.8,;7.06,-51.32,;5.71,-52.09,;4.38,-51.32,;4.38,-49.77,;5.71,-49,;7.02,-49.92,;8.41,-49.25,;9.95,-50.15,;11.22,-49.41,;12.5,-50.14,;12.51,-51.63,;11.23,-52.37,;9.95,-51.63,;9.17,-46.49,;8.38,-45.16,;10.71,-46.47,;11.47,-45.13,;13.01,-44.95,;13.31,-43.44,;11.97,-42.68,;10.83,-43.72,)| | ||
Structure |