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TargetRenin
LigandBDBM50330345
Substrate/Competitorn/a
Meas. Tech.ChEMBL_501175
IC50 0.039±n/a nM
Citation Bezençon OBur DWeller TRichard-Bildstein SRemen LSifferlen TCorminboeuf OGrisostomi CBoss CPrade LDelahaye STreiber AStrickner PBinkert CHess PSteiner BFischli W Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors. J Med Chem 52:3689-702 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50330345
n/a
NameBDBM50330345
Synonyms:CHEMBL1276275 | N-(2-(7-(((3R,4R)-4-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl)piperidin-3-yloxy)methyl)-3,4-dihydroquinolin-1(2H)-yl)ethyl)acetamide | Ro-66-1168
TypeSmall organic molecule
Emp. Form.C36H47N3O5
Mol. Mass.601.7755
SMILESCOc1ccccc1COCCCOc1ccc(cc1)[C@H]1CCNC[C@@H]1OCc1ccc2CCCN(CCNC(C)=O)c2c1 |r|
Structure
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