| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor Jun |
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| Ligand | BDBM50295170 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_573443 (CHEMBL1061338) |
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| IC50 | 71±n/a nM |
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| Citation |  Beutler, JA; Kang, MI; Robert, F; Clement, JA; Pelletier, J; Colburn, NH; McKee, TC; Goncharova, E; McMahon, JB; Henrich, CJ Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition. J Nat Prod72:503-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor Jun |
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| Name: | Transcription factor Jun |
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| Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 |
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| Type: | n/a |
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| Mol. Mass.: | 35683.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05412 |
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| Residue: | 331 |
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| Sequence: | MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
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| BDBM50295170 |
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| n/a |
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| Name | BDBM50295170 |
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| Synonyms: | 6R-senecionylchaparrin | CHEMBL564009 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34O9 |
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| Mol. Mass. | 478.5321 |
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| SMILES | [#6]-[#6@H]-1-[#6@@H](-[#8])[C@@]2([#8])[#8]-[#6][C@]34[#6@H]2[C@@]2([#6])[#6@H](-[#8])-[#6@@H](-[#8])-[#6]=[#6](-[#6])-[#6@@H]2-[#6@@H](-[#8]-[#6](=O)\[#6]=[#6](\[#6])-[#6])-[#6@H]3-[#8]-[#6](=O)-[#6]-[#6@@H]-14 |r,t:17,TLB:3:2:9:6.7,0:1:9:6.7,32:33:9:6.7| |
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| Structure | 
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