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TargetBifunctional epoxide hydrolase 2
LigandBDBM25737
Substrate/Competitorn/a
Meas. Tech.ChEMBL_580015 (CHEMBL1051703)
IC50 5±n/a nM
Citation Shen, HCDing, FXWang, SDeng, QZhang, XChen, YZhou, GXu, SChen, HSTong, XTong, VMitra, KKumar, STsai, CStevenson, ASPai, LYAlonso-Galicia, MChen, XSoisson, SMRoy, SZhang, BTata, JRBerger, JPColletti, SL Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. J Med Chem52:5009-12 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bifunctional epoxide hydrolase 2
Name:Bifunctional epoxide hydrolase 2
Synonyms:Ephx2 | Epoxide hydrolase 2 | HYES_RAT
Type:PROTEIN
Mol. Mass.:62337.15
Organism:Rattus norvegicus
Description:ChEMBL_1465995
Residue:554
Sequence:
MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
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  Blast E-value cutoff:
BDBM25737
n/a
NameBDBM25737
Synonyms:12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid | CHEMBL215387 | US10383835, Compound 700 | Urea-based compound, 18
TypeSmall organic molecule
Emp. Form.C23H40N2O3
Mol. Mass.392.5753
SMILESOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:25:20:27:24.23.26,25:24:20.21.19:27,THB:23:22:19:24.25.26,23:24:19:22.21.27|
Structure
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