Reaction Details |
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Target | Hydroxycarboxylic acid receptor 2 |
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Ligand | BDBM50298002 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_585069 (CHEMBL1054335) |
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IC50 | 150±n/a nM |
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Citation | Schmidt, D; Smenton, A; Raghavan, S; Carballo-Jane, E; Lubell, S; Ciecko, T; Holt, TG; Wolff, M; Taggart, A; Wilsie, L; Krsmanovic, M; Ren, N; Blom, D; Cheng, K; McCann, PE; Gerard Waters, M; Tata, J; Colletti, S Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia. Bioorg Med Chem Lett19:4768-72 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hydroxycarboxylic acid receptor 2 |
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Name: | Hydroxycarboxylic acid receptor 2 |
Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41868.22 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
Residue: | 363 |
Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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BDBM50298002 |
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n/a |
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Name | BDBM50298002 |
Synonyms: | (+/-)-5-(2,5-difluorophenyl)-3-(1H-tetrazol-5-yl)-4,5,6,7-tetrahydro-1H-indazole | CHEMBL565163 |
Type | Small organic molecule |
Emp. Form. | C14H12F2N6 |
Mol. Mass. | 302.2821 |
SMILES | Fc1ccc(F)c(c1)C1CCc2[nH]nc(c2C1)-c1nnn[nH]1 |
Structure |
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