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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50298002
Substrate/Competitorn/a
Meas. Tech.ChEMBL_585069 (CHEMBL1054335)
IC50 150±n/a nM
Citation Schmidt, DSmenton, ARaghavan, SCarballo-Jane, ELubell, SCiecko, THolt, TGWolff, MTaggart, AWilsie, LKrsmanovic, MRen, NBlom, DCheng, KMcCann, PEGerard Waters, MTata, JColletti, S Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia. Bioorg Med Chem Lett19:4768-72 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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  Blast E-value cutoff:
BDBM50298002
n/a
NameBDBM50298002
Synonyms:(+/-)-5-(2,5-difluorophenyl)-3-(1H-tetrazol-5-yl)-4,5,6,7-tetrahydro-1H-indazole | CHEMBL565163
TypeSmall organic molecule
Emp. Form.C14H12F2N6
Mol. Mass.302.2821
SMILESFc1ccc(F)c(c1)C1CCc2[nH]nc(c2C1)-c1nnn[nH]1
Structure
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