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TargetReceptor-interacting serine/threonine-protein kinase 2
LigandBDBM50095227
Substrate/Competitorn/a
Meas. Tech.ChEMBL_587119 (CHEMBL1051329)
IC50 26±n/a nM
Citation Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P The selectivity of protein kinase inhibitors: a further update. Biochem J408:297-315 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 2
Name:Receptor-interacting serine/threonine-protein kinase 2
Synonyms:CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50095227
n/a
NameBDBM50095227
Synonyms:(6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)-amine | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine | CHEMBL97771 | US10548897, Compound 2
TypeSmall organic molecule
Emp. Form.C22H19N3O3
Mol. Mass.373.4046
SMILESCOc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Structure
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