| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
|---|
| Ligand | BDBM50298223 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_586379 (CHEMBL1061944) |
|---|
| IC50 | 2700±n/a nM |
|---|
| Citation |  Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P The selectivity of protein kinase inhibitors: a further update. Biochem J408:297-315 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Sgk1 |
|---|
| Name: | Serine/threonine-protein kinase Sgk1 |
|---|
| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 48954.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
|---|
| Residue: | 431 |
|---|
| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
|
|
|
|---|
| BDBM50298223 |
|---|
| n/a |
|---|
| Name | BDBM50298223 |
|---|
| Synonyms: | CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fluorophenyl)-3H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H9FN6 |
|---|
| Mol. Mass. | 244.2278 |
|---|
| SMILES | Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
