Reaction Details |
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Target | Calcium/calmodulin-dependent protein kinase type IV |
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Ligand | BDBM5445 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_586318 (CHEMBL1060179) |
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Kd | >10000±n/a nM |
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Citation | Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol26:127-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Calcium/calmodulin-dependent protein kinase type IV |
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Name: | Calcium/calmodulin-dependent protein kinase type IV |
Synonyms: | CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 51919.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1459854 |
Residue: | 473 |
Sequence: | MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
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BDBM5445 |
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n/a |
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Name | BDBM5445 |
Synonyms: | CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapatinib | N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine | N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine | Tykerb | US10507209, Compound Lapatinib | US10822334, Compound Lapatinib | US9730934, Lapatinib ditosylate | cid_208908 |
Type | Small organic molecule |
Emp. Form. | C29H26ClFN4O4S |
Mol. Mass. | 581.058 |
SMILES | CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 |
Structure |
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