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TargetCannabinoid receptor 1
LigandBDBM50298915
Substrate/Competitorn/a
Meas. Tech.ChEMBL_588141 (CHEMBL1049258)
Ki 56±n/a nM
Citation Silvestri, RLigresti, ALa Regina, GPiscitelli, FGatti, VBrizzi, APasquini, SLavecchia, AAllarà, MFantini, NCarai, MANovellino, EColombo, GDi Marzo, VCorelli, F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem17:5549-64 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50298915
n/a
NameBDBM50298915
Synonyms:CHEMBL572860 | N-Cycloheptyl-1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide
TypeSmall organic molecule
Emp. Form.C24H28F2N4O
Mol. Mass.426.5021
SMILESCc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NC1CCCCCC1 |(27.65,-39.95,;27.02,-38.54,;27.79,-37.22,;26.76,-36.06,;25.36,-36.7,;24.02,-35.93,;25.51,-38.22,;24.37,-39.25,;22.87,-38.93,;22.24,-37.52,;22.1,-40.27,;23.12,-41.41,;24.53,-40.79,;25.87,-41.56,;27.19,-40.79,;28.53,-41.56,;28.53,-43.1,;29.87,-43.87,;27.19,-43.87,;25.87,-43.1,;24.53,-43.87,;20.56,-40.43,;19.66,-39.19,;19.94,-41.84,;18.38,-42.01,;17.88,-43.44,;16.43,-43.94,;15.13,-43.11,;14.97,-41.59,;16.06,-40.5,;17.61,-40.68,)|
Structure
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