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TargetCannabinoid receptor 1
LigandBDBM50298919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_588141 (CHEMBL1049258)
Ki 54±n/a nM
Citation Silvestri, RLigresti, ALa Regina, GPiscitelli, FGatti, VBrizzi, APasquini, SLavecchia, AAllarà, MFantini, NCarai, MANovellino, EColombo, GDi Marzo, VCorelli, F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem17:5549-64 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50298919
n/a
NameBDBM50298919
Synonyms:CHEMBL574971 | N-[2-(3,4-Dichlorophenyl)ethyl]1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide
TypeSmall organic molecule
Emp. Form.C25H22Cl2F2N4O
Mol. Mass.503.371
SMILESCc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NCCc1ccc(Cl)c(Cl)c1 |(30.25,-15.79,;29.78,-14.32,;30.68,-13.07,;29.78,-11.83,;28.32,-12.31,;27.07,-11.4,;28.32,-13.84,;27.07,-14.75,;25.61,-14.27,;25.13,-12.81,;24.7,-15.52,;25.61,-16.77,;27.07,-16.29,;28.32,-17.19,;29.72,-16.57,;30.96,-17.47,;30.81,-19,;32.05,-19.9,;29.4,-19.63,;28.15,-18.72,;26.75,-19.34,;23.16,-15.52,;22.39,-14.18,;22.39,-16.84,;20.86,-16.84,;20.09,-18.18,;18.55,-18.18,;17.78,-16.84,;16.24,-16.84,;15.47,-18.18,;13.93,-18.18,;16.24,-19.51,;15.47,-20.85,;17.78,-19.51,)|
Structure
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