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TargetCannabinoid receptor 1
LigandBDBM50298923
Substrate/Competitorn/a
Meas. Tech.ChEMBL_588141
Ki 560±n/a nM
Citation Silvestri RLigresti ALa Regina GPiscitelli FGatti VBrizzi APasquini SLavecchia AAllarà MFantini NCarai MANovellino EColombo GDi Marzo VCorelli F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem 17:5549-64 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50298923
n/a
NameBDBM50298923
Synonyms:CHEMBL573099 | N-(4-Chlorophenyl)1-(2,4-difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide
TypeSmall organic molecule
Emp. Form.C23H19ClF2N4O
Mol. Mass.440.873
SMILESCc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)Nc1ccc(Cl)cc1 |(3.04,-1.34,;2.57,.12,;3.47,1.36,;2.57,2.61,;1.1,2.13,;-.14,3.04,;1.1,.59,;-.14,-.31,;-1.61,.17,;-2.08,1.63,;-2.51,-1.08,;-1.61,-2.32,;-.14,-1.85,;1.1,-2.76,;2.51,-2.13,;3.76,-3.03,;3.6,-4.57,;4.84,-5.47,;2.19,-5.19,;.94,-4.28,;-.47,-4.91,;-4.05,-1.08,;-4.82,.25,;-4.82,-2.42,;-6.36,-2.42,;-7.13,-3.75,;-8.67,-3.75,;-9.44,-2.42,;-10.98,-2.42,;-8.67,-1.08,;-7.13,-1.08,)|
Structure
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