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TargetCannabinoid receptor 1
LigandBDBM50298935
Substrate/Competitorn/a
Meas. Tech.ChEMBL_588141
Ki 5.6±n/a nM
Citation Silvestri RLigresti ALa Regina GPiscitelli FGatti VBrizzi APasquini SLavecchia AAllarà MFantini NCarai MANovellino EColombo GDi Marzo VCorelli F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem 17:5549-64 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50298935
n/a
NameBDBM50298935
Synonyms:CHEMBL575382 | N-(Adamant-1-yl)1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide
TypeSmall organic molecule
Emp. Form.C27H30Cl2N4O
Mol. Mass.497.459
SMILESCc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:23:24:27:31.30.29,THB:23:24:27.26.31:29,25:26:29:33.24.32,25:24:27.26.31:29,32:24:27:31.30.29,32:30:27:33.25.24,(1.92,-40.22,;2.36,-38.57,;3.89,-38.49,;4.29,-36.99,;3,-36.16,;2.91,-34.62,;1.8,-37.13,;.31,-36.74,;-.25,-35.29,;.6,-34,;-1.79,-35.38,;-2.19,-36.87,;-.89,-37.71,;-.8,-39.25,;-2.1,-40.09,;-2.01,-41.63,;-.64,-42.33,;-.55,-43.87,;.65,-41.48,;2.03,-42.18,;.57,-39.95,;-2.76,-34.18,;-2.21,-32.74,;-4.28,-34.43,;-5.25,-33.23,;-6.2,-34.42,;-7.52,-33.9,;-8.92,-34.29,;-7.8,-33.1,;-7.81,-31.71,;-6.55,-31.26,;-7.52,-32.42,;-5.24,-31.8,;-6.56,-33.55,)|
Structure
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