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TargetCannabinoid receptor 1
LigandBDBM50298937
Substrate/Competitorn/a
Meas. Tech.ChEMBL_588141
Ki 36±n/a nM
Citation Silvestri RLigresti ALa Regina GPiscitelli FGatti VBrizzi APasquini SLavecchia AAllarà MFantini NCarai MANovellino EColombo GDi Marzo VCorelli F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem 17:5549-64 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50298937
n/a
NameBDBM50298937
Synonyms:CHEMBL575395 | N-Cyclopentyl-1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide
TypeSmall organic molecule
Emp. Form.C22H24Cl2N4O
Mol. Mass.431.358
SMILESCc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NC1CCCC1 |(13.91,-22.91,;14.79,-21.64,;16.32,-21.61,;16.76,-20.13,;15.5,-19.26,;15.46,-17.72,;14.28,-20.19,;12.8,-19.75,;12.29,-18.29,;13.16,-17.03,;10.75,-18.33,;10.31,-19.81,;11.57,-20.69,;11.61,-22.23,;10.3,-23.03,;10.34,-24.57,;11.69,-25.3,;11.72,-26.85,;13,-24.5,;14.35,-25.24,;12.96,-22.97,;9.81,-17.11,;10.4,-15.69,;8.29,-17.31,;7.35,-16.09,;5.81,-16.13,;5.3,-14.67,;6.52,-13.74,;7.79,-14.61,)|
Structure
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