| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
|---|
| Ligand | BDBM50299358 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_590268 (CHEMBL1052803) |
|---|
| Ki | 27±n/a nM |
|---|
| Citation |  Scott, JD; Miller, MW; Li, SW; Lin, SI; Vaccaro, HA; Hong, L; Mullins, DE; Guzzi, M; Weinstein, J; Hodgson, RA; Varty, GB; Stamford, AW; Chan, TY; McKittrick, BA; Greenlee, WJ; Priestley, T; Parker, EM Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett19:6018-22 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V1b receptor |
|---|
| Name: | Vasopressin V1b receptor |
|---|
| Synonyms: | Avpr1b | V1BR_RAT | VASOPRESSIN V1B | Vasopressin V1b receptor | Vasopressin receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 47104.48 |
|---|
| Organism: | RAT |
|---|
| Description: | VASOPRESSIN V1B AVPR1B RAT::P48974 |
|---|
| Residue: | 425 |
|---|
| Sequence: | MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLG
RHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQG
SGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREE
RRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFS
VQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGS
KPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATM
ETSIF
|
|
|
|---|
| BDBM50299358 |
|---|
| n/a |
|---|
| Name | BDBM50299358 |
|---|
| Synonyms: | 1-(2-(1-(2,4-dimethoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)ethylsulfonyl)-N-isopentylpiperidin-4-amine | CHEMBL575796 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H43N3O6S2 |
|---|
| Mol. Mass. | 593.798 |
|---|
| SMILES | COc1ccc(c(OC)c1)S(=O)(=O)N1C(CCS(=O)(=O)N2CCC(CC2)NCCC(C)C)CCc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
