| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 9 |
|---|
| Ligand | BDBM10880 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_592386 (CHEMBL1036959) |
|---|
| Ki | 25±n/a nM |
|---|
| Citation |  Lopez, M; Paul, B; Hofmann, A; Morizzi, J; Wu, QK; Charman, SA; Innocenti, A; Vullo, D; Supuran, CT; Poulsen, SA S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J Med Chem52:6421-32 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 9 |
|---|
| Name: | Carbonic anhydrase 9 |
|---|
| Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49669.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 459 |
|---|
| Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
|---|
| BDBM10880 |
|---|
| n/a |
|---|
| Name | BDBM10880 |
|---|
| Synonyms: | AZA | AZA2 | AZM acetazolamide | Acerazolamide, AAZ | Acetazolamide | Acetazolamide (AAZ) | Acetazolamide (AZA) | Acetazolamide (AZM) | Acetazolamide, 5 | Acetazolamide, AAZ | Acetazolamide, AZA | Acetazolamide, AZM | CHEMBL20 | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Sulfonamide, 1 | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide | sulfonamide 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C4H6N4O3S2 |
|---|
| Mol. Mass. | 222.245 |
|---|
| SMILES | CC(=O)Nc1nnc(s1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
