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TargetLegumain
LigandBDBM50378268
Substrate/Competitorn/a
Meas. Tech.ChEMBL_589116 (CHEMBL1038469)
IC50 2.6±n/a nM
Citation Ovat, AMuindi, FFagan, CBrouner, MHansell, EDvorák, JSojka, DKopácek, PMcKerrow, JHCaffrey, CRPowers, JC Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem52:7192-210 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Legumain
Name:Legumain
Synonyms:Asparaginyl Endopeptidase (AE) | Legumain-like protease precursor
Type:Enzyme
Mol. Mass.:49038.15
Organism:Ixodes ricinus
Description:IrAE was expressed and produced in Pichia pastoris.
Residue:441
Sequence:
MLSLRSILSLLALASLFLVASGTSVPTSKSQASADAKLWALLVAGSNGYYNYRHQADICH
AYHVLHNHGIPDERIVVMMYDDIAHDPSNPTPGIIINHLNGSNVYAGVPKDYTGDLVTPK
NFLSILQGKKIKGGSGKVIASGPNDHVFVFFADHGAPGLIAFPNDDLQATNLSRVIKRMH
KQKKFGKLVFYVEACESGSMFENLLPDDINVYATTAANSDESSYACYYDDLRQTYLGDVY
SVNWMEDSDREDLHKETLLKQFKIVRSETNTSHVMEFGDLKIANLKVSEFQGAKSTPPIV
LPKAPLDAVDSRDVPIAIVRKKLQKATDPQIKLSLKHELDQMLRNRAFLKEKMVEIVSFV
ALGDAEKTEQLLKAKIPLRDHTCYEQAVRYFDTTCFELSANPHALAHLRLLVNMCEEKIS
VSEIREAMDNVCTHPTVIGIV
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  Blast E-value cutoff:
BDBM50378268
n/a
NameBDBM50378268
Synonyms:CHEMBL573433
TypeSmall organic molecule
Emp. Form.C39H44N8O6
Mol. Mass.720.8167
SMILESC[C@H](NC(=O)[C@@H](C)NC(=O)N1CCNCC1)C(=O)NN(CC(N)=O)C(=O)C=CC(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r,w:26.26|
Structure
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