Reaction Details |
| Report a problem with these data |
Target | Legumain |
---|
Ligand | BDBM50378274 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_589116 (CHEMBL1038469) |
---|
IC50 | 0.14±n/a nM |
---|
Citation | Ovat, A; Muindi, F; Fagan, C; Brouner, M; Hansell, E; Dvorák, J; Sojka, D; Kopácek, P; McKerrow, JH; Caffrey, CR; Powers, JC Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem52:7192-210 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Legumain |
---|
Name: | Legumain |
Synonyms: | Asparaginyl Endopeptidase (AE) | Legumain-like protease precursor |
Type: | Enzyme |
Mol. Mass.: | 49038.15 |
Organism: | Ixodes ricinus |
Description: | IrAE was expressed and produced in Pichia pastoris. |
Residue: | 441 |
Sequence: | MLSLRSILSLLALASLFLVASGTSVPTSKSQASADAKLWALLVAGSNGYYNYRHQADICH
AYHVLHNHGIPDERIVVMMYDDIAHDPSNPTPGIIINHLNGSNVYAGVPKDYTGDLVTPK
NFLSILQGKKIKGGSGKVIASGPNDHVFVFFADHGAPGLIAFPNDDLQATNLSRVIKRMH
KQKKFGKLVFYVEACESGSMFENLLPDDINVYATTAANSDESSYACYYDDLRQTYLGDVY
SVNWMEDSDREDLHKETLLKQFKIVRSETNTSHVMEFGDLKIANLKVSEFQGAKSTPPIV
LPKAPLDAVDSRDVPIAIVRKKLQKATDPQIKLSLKHELDQMLRNRAFLKEKMVEIVSFV
ALGDAEKTEQLLKAKIPLRDHTCYEQAVRYFDTTCFELSANPHALAHLRLLVNMCEEKIS
VSEIREAMDNVCTHPTVIGIV
|
|
|
BDBM50378274 |
---|
n/a |
---|
Name | BDBM50378274 |
Synonyms: | CHEMBL573437 |
Type | Small organic molecule |
Emp. Form. | C27H37N7O9 |
Mol. Mass. | 603.6242 |
SMILES | CCOC(=O)C=CC(=O)N(CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)N1CCN(CC1)C(=O)OCc1ccccc1 |r,w:6.6| |
Structure |
|