Reaction Details |
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Target | Legumain |
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Ligand | BDBM50378280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_589116 (CHEMBL1038469) |
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IC50 | 0.52±n/a nM |
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Citation | Ovat, A; Muindi, F; Fagan, C; Brouner, M; Hansell, E; Dvorák, J; Sojka, D; Kopácek, P; McKerrow, JH; Caffrey, CR; Powers, JC Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem52:7192-210 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Legumain |
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Name: | Legumain |
Synonyms: | Asparaginyl Endopeptidase (AE) | Legumain-like protease precursor |
Type: | Enzyme |
Mol. Mass.: | 49038.15 |
Organism: | Ixodes ricinus |
Description: | IrAE was expressed and produced in Pichia pastoris. |
Residue: | 441 |
Sequence: | MLSLRSILSLLALASLFLVASGTSVPTSKSQASADAKLWALLVAGSNGYYNYRHQADICH
AYHVLHNHGIPDERIVVMMYDDIAHDPSNPTPGIIINHLNGSNVYAGVPKDYTGDLVTPK
NFLSILQGKKIKGGSGKVIASGPNDHVFVFFADHGAPGLIAFPNDDLQATNLSRVIKRMH
KQKKFGKLVFYVEACESGSMFENLLPDDINVYATTAANSDESSYACYYDDLRQTYLGDVY
SVNWMEDSDREDLHKETLLKQFKIVRSETNTSHVMEFGDLKIANLKVSEFQGAKSTPPIV
LPKAPLDAVDSRDVPIAIVRKKLQKATDPQIKLSLKHELDQMLRNRAFLKEKMVEIVSFV
ALGDAEKTEQLLKAKIPLRDHTCYEQAVRYFDTTCFELSANPHALAHLRLLVNMCEEKIS
VSEIREAMDNVCTHPTVIGIV
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BDBM50378280 |
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n/a |
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Name | BDBM50378280 |
Synonyms: | CHEMBL576557 |
Type | Small organic molecule |
Emp. Form. | C25H35N5O8 |
Mol. Mass. | 533.5741 |
SMILES | CCOC(=O)C=CC(=O)N(CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)OCc1ccccc1)[C@@H](C)CC |r,w:6.6| |
Structure |
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