| Reaction Details |
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 | Report a problem with these data |
| Target | Malate dehydrogenase, mitochondrial |
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| Ligand | BDBM50300046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_593431 (CHEMBL1041437) |
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| IC50 | 4400±n/a nM |
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| Citation |  Becker, A; Kohfeld, S; Lader, A; Preu, L; Pies, T; Wieking, K; Ferandin, Y; Knockaert, M; Meijer, L; Kunick, C Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). Eur J Med Chem45:335-42 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malate dehydrogenase, mitochondrial |
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| Name: | Malate dehydrogenase, mitochondrial |
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| Synonyms: | MDH2 | MDHM_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35512.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456625 |
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| Residue: | 338 |
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| Sequence: | MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
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| BDBM50300046 |
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| n/a |
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| Name | BDBM50300046 |
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| Synonyms: | CHEMBL583199 | Pentyl 6-oxo-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine-9-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N2O3 |
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| Mol. Mass. | 362.4217 |
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| SMILES | CCCCCOC(=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 |
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| Structure | 
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