| Reaction Details |
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 | Report a problem with these data |
| Target | Malate dehydrogenase, mitochondrial |
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| Ligand | BDBM50300054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_593431 (CHEMBL1041437) |
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| IC50 | 1800±n/a nM |
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| Citation |  Becker, A; Kohfeld, S; Lader, A; Preu, L; Pies, T; Wieking, K; Ferandin, Y; Knockaert, M; Meijer, L; Kunick, C Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). Eur J Med Chem45:335-42 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Malate dehydrogenase, mitochondrial |
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| Name: | Malate dehydrogenase, mitochondrial |
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| Synonyms: | MDH2 | MDHM_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35512.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456625 |
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| Residue: | 338 |
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| Sequence: | MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
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| BDBM50300054 |
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| n/a |
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| Name | BDBM50300054 |
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| Synonyms: | 9-Bromo-5-(4-methoxybenzyl)-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one | CHEMBL568703 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19BrN2O2 |
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| Mol. Mass. | 447.324 |
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| SMILES | COc1ccc(CN2c3ccccc3-c3[nH]c4ccc(Br)cc4c3CC2=O)cc1 |
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| Structure | 
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