| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 14 |
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| Ligand | BDBM50300203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592894 (CHEMBL1048397) |
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| Ki | 7800±n/a nM |
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| Citation |  Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. J Med Chem53:850-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 14 |
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| Name: | Carbonic anhydrase 14 |
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| Synonyms: | CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37665.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human (cloned) isozyme. |
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| Residue: | 337 |
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| Sequence: | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
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| BDBM50300203 |
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| n/a |
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| Name | BDBM50300203 |
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| Synonyms: | (S)-6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | 6-(1S-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one | CHEMBL572366 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18O4 |
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| Mol. Mass. | 262.301 |
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| SMILES | COc1cc2oc(=O)ccc2cc1[C@@H](O)CC(C)C |r| |
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| Structure | 
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