Reaction Details |
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Target | Protein-tyrosine kinase 2-beta |
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Ligand | BDBM50301356 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_599545 (CHEMBL1037540) |
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IC50 | 110±n/a nM |
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Citation | Allen, JG; Lee, MR; Han, CY; Scherrer, J; Flynn, S; Boucher, C; Zhao, H; O'Connor, AB; Roveto, P; Bauer, D; Graceffa, R; Richards, WG; Babij, P Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells. Bioorg Med Chem Lett19:4924-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-tyrosine kinase 2-beta |
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Name: | Protein-tyrosine kinase 2-beta |
Synonyms: | FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK |
Type: | Protein |
Mol. Mass.: | 115868.80 |
Organism: | Homo sapiens (Human) |
Description: | Q14289 |
Residue: | 1009 |
Sequence: | MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
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BDBM50301356 |
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n/a |
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Name | BDBM50301356 |
Synonyms: | CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-4-(methylamino)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C29H25N5O5 |
Mol. Mass. | 523.5393 |
SMILES | CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1 |
Structure |
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