| Reaction Details |
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 | Report a problem with these data |
| Target | Focal adhesion kinase 1 |
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| Ligand | BDBM50301357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599544 (CHEMBL1037539) |
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| IC50 | >125000±n/a nM |
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| Citation |  Allen, JG; Lee, MR; Han, CY; Scherrer, J; Flynn, S; Boucher, C; Zhao, H; O'Connor, AB; Roveto, P; Bauer, D; Graceffa, R; Richards, WG; Babij, P Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells. Bioorg Med Chem Lett19:4924-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Focal adhesion kinase 1 |
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| Name: | Focal adhesion kinase 1 |
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| Synonyms: | FADK 1 | FAK | FAK1 | FAK1_HUMAN | FLT4 | FRNK | Focal adhesion kinase (FAK) | Focal adhesion kinase (PTK2) | Focal adhesion kinase 1 (FAK) | Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 | Focal adhesion kinase-related nonkinase | PPP1R71 | PTK2 | Protein phosphatase 1 regulatory subunit 71 | Protein-tyrosine kinase 2 | VHL/Focal adhesion kinase 1 | p125FAK | pp125FAK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 119233.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q05397 |
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| Residue: | 1052 |
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| Sequence: | MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE
IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
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| BDBM50301357 |
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| n/a |
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| Name | BDBM50301357 |
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| Synonyms: | CHEMBL572237 | N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-4-(dimethylamino)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H27N5O5 |
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| Mol. Mass. | 537.5659 |
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| SMILES | COc1cc2nccc(Oc3ccc(NC(=O)c4c(ccn(-c5ccccc5)c4=O)N(C)C)nc3)c2cc1OC |
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| Structure | 
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