| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-carbonic anhydrase 1 |
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| Ligand | BDBM50221406 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599731 (CHEMBL1048175) |
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| Ki | 126±n/a nM |
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| Citation |  Maresca, A; Carta, F; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. Bioorg Med Chem Lett19:4929-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-carbonic anhydrase 1 |
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| Name: | Beta-carbonic anhydrase 1 |
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| Synonyms: | β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 18186.06 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays. |
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| Residue: | 163 |
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| Sequence: | MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
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| BDBM50221406 |
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| n/a |
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| Name | BDBM50221406 |
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| Synonyms: | 6-acetamido-4-hydroxy-3-((4-sulfamoylphenyl)diazenyl)naphthalene-2,7-disulfonic acid | 6-acetylamino-4-hydroxy-3-(4-sulfamoyl-phenylazo)-naphthalene-2,7-disulfonic acid | CHEMBL237251 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N4O10S3 |
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| Mol. Mass. | 544.535 |
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| SMILES | CC(=O)Nc1cc2c(O)c(N=Nc3ccc(cc3)S(N)(=O)=O)c(cc2cc1S(O)(=O)=O)S(O)(=O)=O |w:10.9| |
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| Structure | 
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