| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase (ATP-hydrolyzing) |
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| Ligand | BDBM50378443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598031 (CHEMBL1046300) |
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| IC50 | 119±n/a nM |
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| Citation |  Starr, JT; Sciotti, RJ; Hanna, DL; Huband, MD; Mullins, LM; Cai, H; Gage, JW; Lockard, M; Rauckhorst, MR; Owen, RM; Lall, MS; Tomilo, M; Chen, H; McCurdy, SP; Barbachyn, MR 5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett19:5302-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase (ATP-hydrolyzing) |
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| Name: | DNA topoisomerase (ATP-hydrolyzing) |
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| Synonyms: | ParE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70593.66 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | ChEMBL_598031 |
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| Residue: | 638 |
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| Sequence: | NYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTIN
KDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNL
SSSWLEVEITRDGAIYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDAGIFSTTDFK
YNTISERLNESAFLLKNVTLSLTDKRTDESVEFHYENGVQDFVSYLNEDKETLTPVLYFE
GEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLK
EKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLM
ENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNEL
YLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGA
DFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEVGHVYIALPPLYKMSKGK
GKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIE
DLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVF
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| BDBM50378443 |
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| n/a |
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| Name | BDBM50378443 |
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| Synonyms: | CHEMBL568020 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N7O |
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| Mol. Mass. | 373.4112 |
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| SMILES | CCNC(=O)Nc1cn2c(cc(cc2n1)-c1ccc(C)nc1)-c1ncccn1 |
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| Structure | 
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