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TargetDNA topoisomerase (ATP-hydrolyzing)
LigandBDBM50378451
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598031 (CHEMBL1046300)
IC50 258±n/a nM
Citation Starr, JTSciotti, RJHanna, DLHuband, MDMullins, LMCai, HGage, JWLockard, MRauckhorst, MROwen, RMLall, MSTomilo, MChen, HMcCurdy, SPBarbachyn, MR 5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett19:5302-6 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA topoisomerase (ATP-hydrolyzing)
Name:DNA topoisomerase (ATP-hydrolyzing)
Synonyms:ParE
Type:PROTEIN
Mol. Mass.:70593.66
Organism:Streptococcus pneumoniae
Description:ChEMBL_598031
Residue:638
Sequence:
NYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTIN
KDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNL
SSSWLEVEITRDGAIYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDAGIFSTTDFK
YNTISERLNESAFLLKNVTLSLTDKRTDESVEFHYENGVQDFVSYLNEDKETLTPVLYFE
GEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLK
EKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLM
ENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNEL
YLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGA
DFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEVGHVYIALPPLYKMSKGK
GKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIE
DLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50378451
n/a
NameBDBM50378451
Synonyms:CHEMBL578362
TypeSmall organic molecule
Emp. Form.C19H18N8O
Mol. Mass.374.3992
SMILESCCNC(=O)Nc1cn2c(cc(cc2n1)-c1cncnc1)-c1ncc(C)cn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: