Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTranscription factor HES-1
LigandBDBM50378454
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598858
IC50 4100±n/a nM
Citation Arai MAMasada AOhtsuka TKageyama RIshibashi M The first Hes1 dimer inhibitors from natural products. Bioorg Med Chem Lett 19:5778-81 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcription factor HES-1
Name:Transcription factor HES-1
Synonyms:Hairy and enhancer of split 1
Type:PROTEIN
Mol. Mass.:29762.25
Organism:Mus musculus
Description:ChEMBL_598858
Residue:282
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHA
PFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAF
AHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50378454
n/a
NameBDBM50378454
Synonyms:LINDBLADIONE
TypeSmall organic molecule
Emp. Form.C16H14O6
Mol. Mass.302.2788
SMILESCCCC(=O)CC=C1C(=O)C(=O)c2cc(O)c(O)cc2C1=O |w:6.5|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: