| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50302213 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599591 (CHEMBL1040203) |
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| Ki | 2±n/a nM |
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| Citation |  Rotella, DP; McFarlane, GR; Greenfield, A; Grosanu, C; Robichaud, AJ; Denny, RA; Feenstra, RW; Núñez-García, S; Reinders, JH; Neut, Mv; McCreary, A; Kruse, CG; Sullivan, K; Pruthi, F; Lai, M; Zhang, J; Kowal, DM; Carrick, T; Grauer, SM; Navarra, RL; Graf, R; Brennan, J; Marquis, KL; Pausch, MH Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia. Bioorg Med Chem Lett19:5552-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A |
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| Type: | undefined |
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| Mol. Mass.: | 52607.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28223 |
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| Residue: | 471 |
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| Sequence: | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
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| BDBM50302213 |
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| n/a |
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| Name | BDBM50302213 |
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| Synonyms: | (3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)methylamino)methyl)-7,9-dihydro-2H-[1,4]dioxino[2,3-e]indol-8(3H)-one | CHEMBL569251 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24FN3O3 |
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| Mol. Mass. | 421.4641 |
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| SMILES | Fc1ccc2[nH]c3CCC(CNC[C@H]4COc5c6CC(=O)Nc6ccc5O4)Cc3c2c1 |r| |
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| Structure | 
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