Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50302621 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_594779 (CHEMBL1040740) |
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IC50 | 100±n/a nM |
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Citation | Goodwin, NC; Mabon, R; Harrison, BA; Shadoan, MK; Almstead, ZY; Xie, Y; Healy, J; Buhring, LM; DaCosta, CM; Bardenhagen, J; Mseeh, F; Liu, Q; Nouraldeen, A; Wilson, AG; Kimball, SD; Powell, DR; Rawlins, DB Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. J Med Chem52:6201-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | SC5A2_MOUSE | Sglt2 | Slc5a2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2 | sodium-dependent glucose cotransporter 2 (SGLT2) |
Type: | Protein |
Mol. Mass.: | 73014.31 |
Organism: | Mus musculus (Mouse) |
Description: | Q923I7 |
Residue: | 670 |
Sequence: | MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA
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BDBM50302621 |
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n/a |
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Name | BDBM50302621 |
Synonyms: | (2S,3R,4R,5S)-2-(4-Chloro-3-(4-methoxyphenylthio)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol | CHEMBL577519 |
Type | Small organic molecule |
Emp. Form. | C19H21ClO6S |
Mol. Mass. | 412.884 |
SMILES | COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Sc2ccc(OC)cc2)c1 |r| |
Structure |
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