Reaction Details |
| Report a problem with these data |
Target | Sodium/glucose cotransporter 2 |
---|
Ligand | BDBM50302623 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_594779 (CHEMBL1040740) |
---|
IC50 | 23±n/a nM |
---|
Citation | Goodwin, NC; Mabon, R; Harrison, BA; Shadoan, MK; Almstead, ZY; Xie, Y; Healy, J; Buhring, LM; DaCosta, CM; Bardenhagen, J; Mseeh, F; Liu, Q; Nouraldeen, A; Wilson, AG; Kimball, SD; Powell, DR; Rawlins, DB Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. J Med Chem52:6201-4 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium/glucose cotransporter 2 |
---|
Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | SC5A2_MOUSE | Sglt2 | Slc5a2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2 | sodium-dependent glucose cotransporter 2 (SGLT2) |
Type: | Protein |
Mol. Mass.: | 73014.31 |
Organism: | Mus musculus (Mouse) |
Description: | Q923I7 |
Residue: | 670 |
Sequence: | MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA
|
|
|
BDBM50302623 |
---|
n/a |
---|
Name | BDBM50302623 |
Synonyms: | (2S,3R,4R,5S)-2-(3-(4-Ethoxybenzyl)-4-methylphenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol | CHEMBL585703 |
Type | Small organic molecule |
Emp. Form. | C22H28O6 |
Mol. Mass. | 388.4541 |
SMILES | CCOc1ccc(Cc2cc(ccc2C)[C@@H]2OC(OC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| |
Structure |
|