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TargetSodium/glucose cotransporter 2
LigandBDBM50302613
Substrate/Competitorn/a
Meas. Tech.ChEMBL_594779 (CHEMBL1040740)
IC50 60±n/a nM
Citation Goodwin, NCMabon, RHarrison, BAShadoan, MKAlmstead, ZYXie, YHealy, JBuhring, LMDaCosta, CMBardenhagen, JMseeh, FLiu, QNouraldeen, AWilson, AGKimball, SDPowell, DRRawlins, DB Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. J Med Chem52:6201-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium/glucose cotransporter 2
Name:Sodium/glucose cotransporter 2
Synonyms:Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 2 | SC5A2_MOUSE | Sglt2 | Slc5a2 | Sodium/glucose cotransporter 2 | Solute carrier family 5 member 2 | sodium-dependent glucose cotransporter 2 (SGLT2)
Type:Protein
Mol. Mass.:73014.31
Organism:Mus musculus (Mouse)
Description:Q923I7
Residue:670
Sequence:
MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA
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  Blast E-value cutoff:
BDBM50302613
n/a
NameBDBM50302613
Synonyms:(2S,3R,4R,5S)-2-(4-Chloro-3-(4-(thiazol-2-yloxy)benzyl)phenyl)-6-methoxytetrahydro-2Hpyran-3,4,5-triol | CHEMBL566076
TypeSmall organic molecule
Emp. Form.C22H22ClNO6S
Mol. Mass.463.931
SMILESCOC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(Oc3nccs3)cc2)c1 |r|
Structure
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