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TargetGlycogen phosphorylase, muscle form
LigandBDBM50303206
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595113 (CHEMBL1050600)
IC50 3500±n/a nM
Citation Zhu, PBi, YXu, JLi, ZLiu, JZhang, LYe, WWu, X Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase. Bioorg Med Chem Lett19:6966-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen phosphorylase, muscle form
Name:Glycogen phosphorylase, muscle form
Synonyms:Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT
Type:Enzyme
Mol. Mass.:97296.32
Organism:Oryctolagus cuniculus (rabbit)
Description:Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Residue:843
Sequence:
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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  Blast E-value cutoff:
BDBM50303206
n/a
NameBDBM50303206
Synonyms:((1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13bR)-9-acetoxy-3a-(6-aminohexylcarbamoyl)-5a,5b,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-8-yl)methyl acetate | CHEMBL566671
TypeSmall organic molecule
Emp. Form.C40H66N2O5
Mol. Mass.654.9624
SMILESCC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)[C@@](C)(COC(C)=O)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)NCCCCCCN |r|
Structure
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