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TargetPteridine reductase 1
LigandBDBM50303505
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596055
Ki 12000±n/a nM
Citation Tulloch LBMartini VPIulek JHuggan JKLee JHGibson CLSmith TKSuckling CJHunter WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem 53:221-9 (2010) [PubMed]  Article
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Pteridine reductase 1
Name:Pteridine reductase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:30459.34
Organism:Leishmania major
Description:ChEMBL_1470027
Residue:288
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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BDBM50303505
n/a
NameBDBM50303505
Synonyms:6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine | CHEMBL566271
TypeSmall organic molecule
Emp. Form.C9H14N6
Mol. Mass.206.2477
SMILESCC1=Nc2c(N)nc(N)nc2NC1(C)C |t:1|
Structure
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