| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pteridine reductase 1 |
|---|
| Ligand | BDBM50303505 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_596055 (CHEMBL1037349) |
|---|
| Ki | 12000±n/a nM |
|---|
| Citation |  Tulloch, LB; Martini, VP; Iulek, J; Huggan, JK; Lee, JH; Gibson, CL; Smith, TK; Suckling, CJ; Hunter, WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem53:221-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pteridine reductase 1 |
|---|
| Name: | Pteridine reductase 1 |
|---|
| Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30459.34 |
|---|
| Organism: | Leishmania major |
|---|
| Description: | ChEMBL_1470027 |
|---|
| Residue: | 288 |
|---|
| Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
|
|
|
|---|
| BDBM50303505 |
|---|
| n/a |
|---|
| Name | BDBM50303505 |
|---|
| Synonyms: | 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine | CHEMBL566271 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H14N6 |
|---|
| Mol. Mass. | 206.2477 |
|---|
| SMILES | CC1=Nc2c(N)nc(N)nc2NC1(C)C |t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
