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TargetPteridine reductase 1
LigandBDBM50303511
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596055
Ki 16400±n/a nM
Citation Tulloch LBMartini VPIulek JHuggan JKLee JHGibson CLSmith TKSuckling CJHunter WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem 53:221-9 (2010) [PubMed]  Article
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Pteridine reductase 1
Name:Pteridine reductase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:30459.34
Organism:Leishmania major
Description:ChEMBL_1470027
Residue:288
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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BDBM50303511
n/a
NameBDBM50303511
Synonyms:2-amino-6-(4-ethylphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | CHEMBL567353
TypeSmall organic molecule
Emp. Form.C15H13N5O
Mol. Mass.279.2966
SMILESCCc1ccc(cc1)-c1[nH]c2nc(N)[nH]c(=O)c2c1C#N
Structure
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