| Reaction Details |
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 | Report a problem with these data |
| Target | Pteridine reductase 1 |
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| Ligand | BDBM50303514 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_596055 (CHEMBL1037349) |
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| Ki | 2600±n/a nM |
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| Citation |  Tulloch, LB; Martini, VP; Iulek, J; Huggan, JK; Lee, JH; Gibson, CL; Smith, TK; Suckling, CJ; Hunter, WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem53:221-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pteridine reductase 1 |
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| Name: | Pteridine reductase 1 |
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| Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30459.34 |
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| Organism: | Leishmania major |
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| Description: | ChEMBL_1470027 |
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| Residue: | 288 |
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| Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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| BDBM50303514 |
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| n/a |
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| Name | BDBM50303514 |
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| Synonyms: | 2-amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | 2-amino-6-(benzo[d][1,3]dioxol-5-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | CHEMBL568414 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9N5O3 |
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| Mol. Mass. | 295.253 |
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| SMILES | Nc1nc2[nH]c(c(C#N)c2c(=O)[nH]1)-c1ccc2OCOc2c1 |
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| Structure | 
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