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TargetPteridine reductase 1
LigandBDBM50303518
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596055
Ki 600±n/a nM
Citation Tulloch LBMartini VPIulek JHuggan JKLee JHGibson CLSmith TKSuckling CJHunter WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem 53:221-9 (2010) [PubMed]  Article
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Pteridine reductase 1
Name:Pteridine reductase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:30459.34
Organism:Leishmania major
Description:ChEMBL_1470027
Residue:288
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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BDBM50303518
n/a
NameBDBM50303518
Synonyms:2,4-diamino-6-(benzylthio)pyrimidin-1-ium | 6-(benzylsulfanyl)pyrimidine-2,4-diamine | CHEMBL566948
TypeSmall organic molecule
Emp. Form.C11H12N4S
Mol. Mass.232.305
SMILESNc1cc(SCc2ccccc2)nc(N)n1
Structure
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