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TargetPteridine reductase 1
LigandBDBM50303519
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596055
Ki 2700±n/a nM
Citation Tulloch LBMartini VPIulek JHuggan JKLee JHGibson CLSmith TKSuckling CJHunter WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem 53:221-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Pteridine reductase 1
Name:Pteridine reductase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:30459.34
Organism:Leishmania major
Description:ChEMBL_1470027
Residue:288
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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BDBM50303519
n/a
NameBDBM50303519
Synonyms:6-[(4'-Methoxybenzyl)sulfanyl]-2,4-pyrimidinediamine | 6-[(4-methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine | CHEMBL577502
TypeSmall organic molecule
Emp. Form.C12H14N4OS
Mol. Mass.262.331
SMILESCOc1ccc(CSc2cc(N)nc(N)n2)cc1
Structure
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