| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor A |
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| Ligand | BDBM50303976 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595237 (CHEMBL1043589) |
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| Ki | 1618±n/a nM |
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| Citation |  Mizuno, CS; Chittiboyina, AG; Shah, FH; Patny, A; Kurtz, TW; Pershadsingh, HA; Speth, RC; Karamyan, VT; Carvalho, PB; Avery, MA Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome. J Med Chem53:1076-85 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor A |
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| Name: | Type-1 angiotensin II receptor A |
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| Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40910.53 |
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| Organism: | RAT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
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| Residue: | 359 |
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| Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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| BDBM50303976 |
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| n/a |
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| Name | BDBM50303976 |
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| Synonyms: | 3'-(2-(4-(2-(1H-Tetrazol-5-yl)ethyl)phenoxy)ethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole | CHEMBL567898 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H32N8O |
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| Mol. Mass. | 520.6281 |
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| SMILES | CCCc1nc2c(C)cc(cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1)-c1nc2ccccc2n1C |
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| Structure | 
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