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TargetHTR6
LigandBDBM86428
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595424
Ki 0.75±n/a nM
Citation de la Fuente TMartín-Fontecha MSallander JBenhamú BCampillo MMedina RAPellissier LPClaeysen SDumuis APardo LLópez-Rodríguez ML Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. J Med Chem 53:1357-69 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HTR6
Name:HTR6
Synonyms:5-HT6 | 5-hydroxytryptamine receptor 6
Type:Enzyme Catalytic Domain
Mol. Mass.:47012.98
Organism:MOUSE
Description:5-HT6 HTR6 MOUSE::Q9R1C8
Residue:440
Sequence:
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQC
RLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQ
VPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCIS
PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHS
GARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNF
FVTDSVEPEIRQHPLGSPMN
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BDBM86428
n/a
NameBDBM86428
Synonyms:SB-258585
TypeSmall organic molecule
Emp. Form.C18H22IN3O3S
Mol. Mass.487.355
SMILESCOc1ccc(NS(=O)(=O)c2ccc(I)cc2)cc1N1CCN(C)CC1
Structure
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